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Voksne kan oppleve anfall, lett blåmerker, feber, frysninger, muskelsmerter, influensa symptomer, fot og ankel hevelse, forvirring, rask frem og tilbake øyebevegelser og tremor. E' stato dimostrato che l'alofantrina prolunga l'intervallo QTc alla dose terapeutica raccomandata ed è un substrato del CYP3A4.

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